Dmpc Pro6/15/2023 From this mixture, two crystalline products are saparable: aescin (haemolytic) and prosapogenin (non-haemolytic) 1, 3. Aescin is a mixture of triterpenoid saponins 4. It exists in two forms, the α- and the β-form from which the latter is haemolytically active and the compound of interest in this study 1. ![]() The aescin molecule is constituted of a large and well-defined head group made of one glucuronic acid and two glucose molecules linked to a lipophilic sapogenin 1, 5, 6. The aglycones of aescin are derivatives of proto-ascigenin, acylated by acetic acid at C-22 and by either angelic or tiglic acids at C-21 1. They can be distinguished by their melting point, the specific rotation, haemolytic index, and solubility in water 1. To the triterpenoid backbone, additional polar groups are attached giving this molecule a polar and an apolar side. Saponins, such as aescin, are consumed on a daily basis as they are found in common foods, such as peanuts, spinach, tomatoes and tea 7, 8.įigure 1(a) shows the molecular structure of β-aescin. ![]() Therefore, it is used to treat chronic venous insufficiency (CVI).Īescin possesses anti-inflammatory and anti-oedematous properties 9. The anti-oedematous effect is attributed to aescin, because in case of a hypoxia it i.a.
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